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The use of glucose and fructose calculated from sweetener disappearance increased in parallel during this time period ( Figure 2).

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The conditional muscle insulin receptor knockout mouse has impaired insulin signaling and decreased insulin-dependent glucose transport, without systemic insulin resistance, but develops metabolic syndrome and dyslipidemia (5).

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Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains".

Use: To improve glycemic control in adult patients with diabetes mellitus.

Insulin resistance is an abnormal condition whereby the receptors of the cells that respond to insulin have lost sensitivity and become "resistant" to insulin.

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Tsui E, Barnie A, Ross S, Parkes R, Zinman B: Intensive insulin therapy with insulin lispro: a randomized trial of continuous subcutaneous insulin infusion versus multiple insulin injections.

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These analogs function very well in continuous subcutaneous insulin infusion (CSII) systems (insulin pumps), resulting in lower HbA 1c concentrations and postprandial blood glucose levels than regular insulin, with less hypoglycemia.

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Metabolic syndrome (MS) is a collection of cardiometabolic risk factors that includes obesity, insulin resistance, hypertension, and dyslipidemia.

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This interest has yielded insulin analogues that are characterized by action profiles that afford more flexible treatment regimens with a lower risk of the development of hypoglycemia ( Table 1 Duration of Action of Standard Insulins and Insulin Analogues.

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Again, using a similar 2-wk paradigm, SIT increased glucose infusion rate by 21% in young men and women 72 h after the last training session during EHC ().

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Regular, also known as short-acting insulin, takes about 30 minutes to reach the bloodstream.

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