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Effects of a 'Drug Holiday' on Bone Mineral Density and Bone Turnover Marker During Bisphosphonate Therapy.
The zoledronic acid was administered every 3 to 4 weeks for 6 doses and then every 3 to 6 months to complete 5 years of treatment.
Maximum of 1g per infusion; greater doses must be divided and separated by at least 1 week.
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Consider risks and benefits of denosumab in such patients.
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Review of the cardiovascular safety of zoledronic acid and other bisphosphonates for the treatment of osteoporosis.
Talk to your doctor about the risks of receiving zoledronic acid injection.
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The fractures occurred earlier in the women taking both Fosamax and Premarin, suggesting an additive effect on bone resorption.
Keep in mind that just because you sign the consent for treatment you do not ever give up your right to later refuse the treatment before or during administration.
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Popular Osteoporosis Drugs Triple Risk Of Painful Bone Necrosis, Study Finds.
The dosage is based on your medical condition (including your function) and response to treatment.
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Long-term effects of the degree of bone remodeling suppression seen with denosumab are unknown.
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My endocronologist wants me to be seen by a neurologist and have a nerve conduction test done.
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The chance of this side-effect occurring after second or third zoledronate infusions is much lower (about 3-4%).
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The interaction between RANK and RANKL is integral to normal bone resorption process.
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These tests showed my thyroid and pituitary gland readings were way off.
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My family doctor agrees with me, also.
My doctor recommended taking extra calcium a few days prior and after the treatment, maybe that's the trick.
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It is taken on a cyclical basis, such as 400 mg for 2 weeks out of every 3-month period.
It has been 2 years since my last infusin and I am still having pain in my hip and legs.
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Nonalcoholic fatty liver disease induced by leuprorelin acetate.
There was a small increase in the risk of inflammatory ocular adverse events within the first 15 days after infusion, as reported with other bisphosphonates.
Your advice is fantastic.
Call your doctor right away if you have muscle aches, cramps, or spasms (especially of the face, feet, or hands); numbness or tingling of the lips, tongue, fingers, or feet; irregular heartbeat; or seizures.
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Importance of receiving adequate calcium and vitamin D supplementation during denosumab therapy, and importance of seeking medical attention if signs or symptoms of hypocalcemia develop (e.
Oral ibandronate is a single-nitrogen bisphosphonate whose efficacy is similar to that of IV ibandronate for the treatment of bone metastases.
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The authors concluded that zoledronic acid had no beneficial effect on the clinical resolution of acute Charcot neuroarthropathy in terms of total immobilization time.
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Although some dentists recommend the use of blood tests to decide who is at risk, this practice is controversial due to a very limited evidence base and should not be used at this time.
Osteoporosis Canada recognizes QUS as a useful tool, especially in areas where dual x-ray absorptiometry (DXA) in not available: it is inexpensive, portable, easy to use and does not involve ionizing radiation (e.
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Drug Administration (FDA) update the drug's labels to “further clarify the duration of use.
Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant illnesses.
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Use with caution in patients on antipsychotics.
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