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I work as an international journalist and I travel a lot to countries with exotic nature. Every time when I am about to direct my steps to regions with malaria I take a course of Chloroquine. It helps me keep away from the disease and come back healthy. These medications can not be taken on a regular basis because of being very strong. So don't forget to consult with your doctor if you plan a trip to contaminated area. Malaria is a horrible disease and if you can prevent it don't hesitate. People talk about awful side effects after taking medications from malaria, but what I think is that vomiting and sweating is better than death anyway. The only side effect I experienced after starting on Chloroquine was mild fatigue. It soon disappeared though. So, think twice and then act!
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Gambian infants suggested that gametocytes time their maturation in the peripheral blood according to regular daily temperature fluctuations in the host to coincide with peak vector densities (), a hypothesis that was not supported by a study of eight Tanzanian children where gametocytes showed elevated peripheral densities between 1530 and 1930 h, well before the peak biting time of 0030 to 0330 h described for the local mosquito vector ().
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The effectiveness of chloroquine against the parasite has declined as some resistant forms of the parasite can effectively neutralize the drug by developing a mechanism that drains chloroquine away from the key area, preventing heme from reaching the necessary concentration.
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In rare instances when access to medical care is not available and the traveler develops a febrile illness consistent with malaria, the reliable supply medication can be self-administered presumptively.
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In our proliferative assay in vitro, we found an inhibitory effect by using 20 μM, and some concerns may arise about the dosage of chloroquine that we used in our experiments in vivo for priming mice.
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It has become a worldwide problem, causing more serious malaria transmission in some areas or countries, recurrence of malaria transmission in areas where malaria transmission was once interrupted, and a significant increase of morbidity and mortality, as well as noticeable increases in the cost of malaria control.
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Introduction Nearly half a billion people are infected with malaria each year and more than a million people die from this disease.
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