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Although the 2 groups showed no difference in the combined endpoint (death or nonfatal MI) at 1 year, a 5-year follow-up analysis revealed that the invasive strategy was associated with significant reductions in death or nonfatal MI.
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All study participants gave written, informed consent, and the institutional review board at Northwestern University approved the study.
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Nonetheless, regardless of the conditions of energisation of the mitochondrial inner membrane, the IC 50 for inhibition of mitochondrial complex I by ranolazine was much higher than its therapeutic concentrations.
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When added to a regimen of maximal dose amlodipine, ranolazine significantly reduced the frequency of angina episodes per week compared with placebo (2.
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Ranolazine improves exercise parameters with no detectable effect on heart rate and blood pressure in patients with chronic stable angina pectoris.
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