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How long does Phenergan take to wear off? Promethazine will start to make you feel sleepy around 20 minutes after you take it and may work for up to 12 hours. If you're taking it for a cough or cold, allergies or nausea, your symptoms should start to improve within 20 minutes. The medicine should work for around 4 to 6 hours.
How long does promethazine stay good? by Drugs.com Promethazine will be mostly out of your system in two to four days. The elimination half-life of a medication is the time it takes for blood levels of the medication to be reduced by half. For Promethazine the half-life is approximately 10 to 19 hours.

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