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The dose was well tolerated; most patients achieved the target dose, and side effects were only slightly more prevalent than in the placebo group.

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Other recent randomized trial data include those of the ADVANCE trial in which treatment with an ACE inhibitor and a thiazide-type diuretic reduced the rate of death but not the composite macrovascular outcome.

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There was some evidence that combination therapy with the DRI aliskiren and an ACEI or ARB provided additional blood pressure reductions compared with monotherapy in patients with mild-to-moderate hypertension, and reduced surrogate markers of organ damage in patients with heart failure or DN ().

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Assessment of the long-term effect of treatment is restricted by the dearth of truly long-term studies; follow-up exceeded 6 months in only one third of head-to-head studies.

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The opinions and statements provided on this website have not been evaluated by the Food and Drug Administration.

Do not stop taking this medication without first talking to your doctor.

The confidence interval was wider for those with diabetes because of their smaller number.

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ARB alone is not an ideal treatment; in fact, at the end of the treatment period, the 24-h proteinuria levels in the telmisartan group were slightly higher than baseline (although the difference did not reach statistical significance).

Increase to maximum dosage of amlodipine 10 mg and valsartan 320 mg once daily, if needed, to control BP.

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