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Based on a new research study published in The Lancet (April, 2005), newspaper headlines around the world are proclaiming that senior citizens should throw away their calcium supplements and turn to prescription drugs as their primary treatment for osteoporosis and bone fractures.
DEXA machines are safe and pose no health risks, but the push to use them earlier and diagnose osteopenia can lead to early, unnecessary and possibly dangerous treatment.
Osteocalcin response to calcium-restricted diet: a helpful tool for the workup of hypercalciuria.
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No information is available yet on the added value of pharmacological treatments when life style interventions are implemented as they should be.
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Approximately 80 percent of the patients in the alendronate groups had increases in lumbar-spine bone mineral density, as compared with 45 percent of those in the placebo group.
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Figures to the right show the normal spine at age 40 and osteoporotic changes at 60 and 70 years of age.
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Twenty-one of the 43 patients had serious adverse effects, and 12 of the 21 continued to take alendronate for a mean of 13 days (median, 9) after the onset of symptoms.
Calcium supplements (500 mg daily in the form of calcium carbonate) and vitamin D supplements (400 IU daily in the United States and 400 to 450 IU daily in the other countries) were provided to all the men.
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Alendronate administration in rats and mice, respectively, showed that normal bone was formed on top of the Alendronate, which was incorporated inside the matrix.
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Fosamax is approved for the treatment of osteoporosis in women that are postmenopausal, treatment of osteoporosis in males, the treatment of Paget's disease, and the treatment of glucocorticoid induced osteoporosis in men and women.
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Both daily and intermittent uses of ibandronate (Boniva) have demonstrated antifracture effectiveness at the spine only.
Zoledronic Acid Works Faster than Alendronate By John Gever, Senior Editor, MedPage Today Published: September 18, 2009 Action Points ---------------------------------------- ----------------------------------- â Explain to interested patients that both zoledronic acid and alendronate are FDA-approved for treating osteoporosis.
The magnitude of fracture reduction predicted by the small increases in BMD we observed with increased calcium intake are also consistent with the findings of our systematic review of calcium supplements and fracture.
Atrial fibrillation: In a clinical trial of zoledronic acid (HORIZON Pivotal Fracture Trial), a few cases of atrial fibrillation were reported, but similar risk was not observed in other clinical trials.
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Also, follow-up should be more vigilant and a chlorhexidine rinse pre- and post-operatively "can be effective" in ensuring socket and wound healing and mucosal coverage of exposed bone, the researchers said.
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