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I have severe bruising on my arms from very thin skin. I have debated for a long time about taking Plavix. I started taking it 9 years ago when I had a very mild heart attack and a stent in a 90% blocked artery. There was another artery that was 60% blocked which they told me should be watched. 6 months ago , I had a heart catheter and they said the blockage was gone, and they didn't know why. My Doctor said that I should continue taking Plavix, and that stopping probably wouldn't help the bruising and thin skin. So that is what I will do.
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To give people with unstable angina an extra boost, their first dose is usually increased to 300 milligrams.
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In some patients, a single dose of 300 mg is given first.
The dosage and length of treatment are based on your medical condition and response to treatment.
It is very important that patients talk with their health care professional about any over-the-counter (OTC) drugs they are taking before starting or while using clopidogrel Consult your health care provider for recommendations based on your specific circumstances.
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This was consistent across subgroups of patients defined by baseline characteristics, and type of fibrinolytics or heparin therapy.
In the study, 24 healthy male smokers (aged 50 years or older) took either placebo or 2 capsules (75 mg of a grape procyanidin extracts and soy phosphatidalcholine), twice daily for 4 weeks.
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Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from clopidogrel, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
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Aspirin will help prevent platelets from making the blood too thick, thereby reducing the risk of a clot.
Prior to scheduling an invasive procedure, patients should inform their clinicians (including dentists) that they are currently taking clopidogrel; clinicians performing the invasive procedure should consult with the prescribing clinician before discontinuing clopidogrel therapy.
The manufacturers have encouraged physicians to prescribe Plavix to patients beyond the scope approved by the FDA.
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For example, Plavix should be taken without food unless your physician directs otherwise.
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Doctors often place stroke and TIA patients on blood thinners to decrease the possibility of the body forming another clot in the blood, which may lead to another stroke and TIA.
Accordingly, PLAVIX may interfere with the metabolism of phenytoin, tamoxifen, tolbutamide, warfarin, torsemide, fluvastatin, and many non-steroidal anti-inflammatory agents, but there are no data with which to predict the magnitude of these interactions.
Plavix should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
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The incidence of the primary end point with such therapy, as predicted, was approximately 3 percent per year.
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Additionally, the incidence of high on-treatment platelet reactivity was reduced in the ticagrelor group compared with those receiving clopidogrel by the end of PCI (81.
Antiplatelet therapies for the treatment of cardiovascular disease.
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The risk of stent thrombosis is highest in the weeks and months after stent placement.
Since clopidogrel is metabolized to its active metabolite by CYP2C19, use of drugs that inhibit the activity of this enzyme would be expected to result in reduced drug levels of the active metabolite of clopidogrel and a reduction in clinical efficacy.
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If Plavix is not the only medication you are currently taking, check with your physician to ensure that grapefruit juice does not affect your medications taken as a whole.
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Based on the current scientific information, the Plavix label has been updated with new warnings about the use of Prilosec and other drugs that inhibit the CYP2C19 enzyme and that could interact with Plavix in the same way.
They do not effectively convert Plavix to its active form because of low CYP 2C19 activity.
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